Allergic resident memory finds a skin niche.

A pathogenic CXCR6+ subset of skin-resident memory CD4+ T cells persists after biologic treatment in human atopic dermatitis, linking relapse to a durable skin niche.

• Why it matters: Mechanisms behind allergic relapse in skin are not well understood, limiting how clinicians can target the cells that remain active after therapy.
• What they did: Asahina et al. identified and characterized a CXCR6+ population within skin-resident memory CD4+ T cells in human atopic dermatitis patients, including after biologic treatment.
• The result: The persistence of this pathogenic subset implies allergic relapse may be supported by long-lived resident T cells in skin, even when biologics are used.

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