Negative data augmentation with region-directed mutations improves TCR-epitope binding and interaction prediction, enhancing model discrimination and robustness.
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vaccines and immunoinformatics approaches
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Cell traversal by Plasmodium sporozoites triggers innate immune responses essential for protective T cell activation, with 100% dependence on cell wounding signals.
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Genetic variation in HLA, IGKV, and HHEX loci significantly influences COVID-19 vaccine-induced neutralizing antibody responses and protection, with HLA linked to reduced breakthrough infections.
- Open access
MS Andrea directly identifies and scores combinatorial peptide modifications, detecting up to four modifications per peptide with higher accuracy than existing tools.
- Open access
AlphaFold2-based PAbFold pipeline accurately predicts linear antibody epitopes from sequence data, successfully identifying epitopes for known and novel antibodies.
- Open access
γδ T cells infiltrate small cell lung cancer (SCLC) tumors and predict improved responses to immunotherapy, highlighting their potential as therapeutic targets.
- Open access
The Virtual Biotech, a multi-agent AI system, improves drug development success rates by 48% and reduces adverse events by 32% through integrated analysis of biological data.
- 1 cites
Cancers evade T cell detection by restricting presentation of p53 neoantigens, with 70% of hotspot mutations avoiding display in tumors.
AI-driven integration of multi-modal single-cell genomics and reverse vaccinology enables de novo design of personalized multi-epitope cancer vaccines, advancing immunotherapy.
- Open access
Proximity-guided graph learning identifies 248 tumour-associated proximity antigens, revealing spatial relationships that enhance targeted cancer therapy.
- Open access
A model incorporating negative frequency-dependent selection accurately predicts pneumococcal vaccine replacement dynamics, guiding surveillance strategies across diverse regions.
- Open access
Bakta and PGAP outperform other tools in annotating diverse prokaryotic genomes, with Bakta excelling in bacteria and PGAP in archaea and challenging assemblies.
- Open access
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