Plectosphaerella cucumerina's carbohydrate-active enzymes enable it to infect multiple plant hosts, with a key GH64 gene driving multihost pathogenicity.
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Nature Microbiology
Nature Portfolio · Microbiology & Mycology · ISSN 2058-5276
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Fusobacterium nucleatum amplifies Bacteroides fragilis-induced neuron loss and gut motility issues, with 2-hydroxybutyric acid worsening neurotoxicity in mice.
Cell traversal by Plasmodium sporozoites triggers innate immune responses essential for protective T cell activation, with 100% dependence on cell wounding signals.
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A generalized lineage nomenclature system enables scalable viral genomic surveillance, exemplified by defining 21 chikungunya virus lineages across 8 founding lineages.
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Wild rice gene OsRLK, mainly found in Oryza rufipogon, enhances nitrogen-use efficiency by promoting beneficial Acinetobacter microbiota, boosting crop yield.
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Active migration of Plasmodium sporozoites through host cells is essential for achieving sterilizing T cell-mediated immunity after vaccination, regardless of intrahepatic development.
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Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating chaperone-mediated autophagy and promoting tumor growth and viral persistence.
A machine-learning framework predicts strain-level phage-host interactions across diverse bacteria with AUROC up to 0.94, independent of phylogenetic constraints.
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VRC01 prophylaxis induces escape mutations in HIV post-infection in 31% of treated individuals, highlighting challenges in antibody-based prevention.
HIDEN-SEQ identifies essential and conditionally essential genes in bacteriophages, revealing new antiviral defense factors across diverse hosts and conditions.
Phage Tn-seq reveals essential genes and enables rapid engineering across diverse phages, including jumbo and hypermodified DNA types.
Pseudomonas aeruginosa drives the expansion of pathogenic IFNγ(+)Th17 cells, causing lung damage in cystic fibrosis with a 2- to 3-fold increase in these subsets.
Functional diversity, rather than taxonomy, drives bacterial recruitment into plant root microbiomes across different hosts and environments.
Sequential gene loss in Salmonella Typhimurium ST34 drives its clonal expansion, with 44,597 genomes revealing a stepwise pathoadaptation process.
In vivo CRISPRi screens reveal that E. coli adapts through distinct genetic strategies, with 20 essential genes varying across strains and conditions in the mouse gut.
Bacterial growth rate varies with environmental and genetic factors, with (p)ppGpp playing a key role in coordinating nutrient signals and growth in Escherichia coli.
AP2-HS regulates environmental induction of sexual conversion in Plasmodium falciparum, involving a feedback loop that controls gdv1 expression and gametocyte formation.
Hedgehog aminopeptidase N (APN) serves as a functional receptor for European and Asian hedgehog merbecoviruses, with a unique binding mode distinct from other coronaviruses.
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Aminopeptidase N serves as a receptor for hedgehog merbecoviruses, with species-specific binding revealed by cryo-EM analysis.
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Prophage-encoding engineered bacteria produce high levels of lytic phage, preventing Salmonella enterica Typhimurium infection and improving survival in mice.
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Cryo-EM structures of Candida albicans Chs1 reveal a druggable translocation channel critical for chitin synthesis and inhibition.
Histone H2B monoubiquitination by Rad6B-Tex1 complex is essential for sexual conversion in Plasmodium parasites, influencing transmission to mosquitoes.
Candidatus Methanoglobus sphaerolipidus DLY3, an archaeon from Archaeoglobi, directly produces methane from long-chain fatty acids, expanding known methanogenic pathways.
Pneumococcal population structure determines how air pollution influences invasive disease risk, with specific lineages and serotypes showing immediate effects.
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