Engineered GPCR-based yeast biosensors have achieved significant performance improvements, enabling diverse practical applications through modular design and optimization.
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Biotechnology advances
Elsevier BV · Microbiology & Mycology · ISSN 0734-9750, 1873-1899
- Impact (2-yr)
- 11.8
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Advances in sequencing and genome editing have significantly improved detection and understanding of extrachromosomal circular DNA (eccDNA), revealing new insights into genome organization.
Enhancing P450 enzyme components with greater degrees of freedom can significantly expand biocatalytic applications in pharmaceutical manufacturing.
- Open access
Flavin-dependent enzymes demonstrate extensive catalytic promiscuity, enabling over 20 distinct non-native reactions through natural and engineered mechanisms.
Integrating enzymatic DNA synthesis, assembly, and MutS-based error correction into a continuous pipeline enhances fidelity and scalability for gene construction.
- Open access
Microorganisms efficiently metabolize liquid n-alkanes, enabling complete mineralization and biocatalytic conversion for environmental and industrial applications.
Expansins and expansin-like proteins influence cell wall properties across diverse organisms, with recent discoveries revealing catalytic activity in some members of the superfamily.
- Open access
- 2 cites
Distinct lignocellulosic and cellulose-derived carriers are essential for safe, effective biofilm-based food fermentations, with specific design and validation criteria identified.
- Open access
Microbial biosynthesis can produce over 10 grams per liter of mevalonate, offering a sustainable and cost-effective alternative to chemical synthesis for industrial use.
Liquid-liquid phase separation enables precise regulation of metabolic processes, with artificial condensates improving biosynthesis and cellular control in engineered systems.
CAR-T cell therapies and cancer nanovaccines show promise but face distinct translational challenges, with recent advances highlighting their potential to reshape cancer treatment.
- Open access
Enzymatic CO2 fixation pathways can be optimized to convert CO2 into valuable products, with potential for scalable, sustainable biocatalytic applications.
Genetic code expansion enables multiplex noncanonical amino acid incorporation through codon compression and novel codon creation, expanding protein engineering capabilities.
Programmable bioengineering and scalable bioprocessing enable fivefold increases in tailored rhamnolipid production from safe, non-pathogenic cell factories.
Alternative proteins could help meet the projected 50% increase in global meat demand by 2050, but large-scale production remains a significant challenge.
Engineering Corynebacterium glutamicum and Escherichia coli has achieved record L-arginine titers up to 92.5 g/L, advancing microbial production capabilities for industrial use.
- 2 cites
AI-assisted and structure-guided methods have advanced the discovery of PET-degrading enzymes with improved industrial relevance, surpassing traditional bioprospecting.
Synthetic microbiomes enable precise, scalable control over metallic nanoparticle synthesis, achieving enhanced robustness, selectivity, and stability.
Artificial carbohydrate synthesis pathways surpass photosynthesis, potentially revolutionizing sustainable carbon fixation and addressing human demand for efficient, scalable production.
Programmable methylation engineering enables scalable biosynthesis of complex alkaloids by optimizing methyltransferase function and cofactor cycling.
Microbial and enzymatic degradation can effectively break down plastics, but only 10-20% of reported cases are reliably validated as true biodegradation.
Engineering translation control enables predictable gene expression by tuning initiation, elongation, and termination processes in biological systems.
Microbial systems have been engineered to significantly enhance the biosynthesis of SAM and its derivatives, enabling sustainable production of high-value compounds.
- 1 cites
3D DNA walkers enable highly sensitive biosensors with programmable movement for detecting foodborne pathogens, advancing food safety monitoring.
- 2 cites
Advances in microbial biosynthesis and fermentation strategies have significantly improved prodigiosin production, with yields reaching new heights and cost reductions.
Embeddings from genome and protein language models enable high-resolution, alignment-free insights into genomics and proteomics, surpassing traditional methods.
Geobacter spp. can extract electrons from solid donors, causing biocorrosion and enabling applications like pollutant degradation and bioproduction.
A comprehensive, disease-agnostic pipeline for antigen prioritization enhances vaccine design by integrating biological and developability criteria, improving candidate selection.
Extremophiles can form resilient biofilms and cause microbiologically influenced corrosion (MIC) in extreme environments, with corrosion mechanisms active under high temperature, salinity, and acidity.
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4