Incorporation of powerful RNA interference targets within nano-enabled co-delivery platforms for broad-spectrum resistance management.

This review identifies effective RNA interference targets for broad-spectrum pest resistance management by outlining four transcription factor–mediated metabolic signaling pathways and penetration resistance mechanisms.

• Why it matters: Pest resistance escalation is linked to conventional pesticide ineffectiveness, threatening global food security and public health, while single-target RNAi focus limits broad-spectrum control.
• What they did: It systematically analyzes four key transcription factor–mediated metabolic signaling pathways and penetration resistance mediated by body wall/intestinal thickening, then proposes nano-enabled co-delivery platform design and synergistic mechanisms.
• The result: The work summarizes application cases and prospects, concluding that it provides abundant synergistic RNAi targets to support multicomponent RNA nano-pesticides for global resistant pests.

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