AI-driven framework AGENT rapidly identified thermostable mRNA-LNP vaccine formulations, achieving 100% bioactivity after 2 months at 37°C in just six iterations.
RNA Interference and Gene Delivery
Moving in Nature Biotechnology.
- Moved this week
- 1
Rebuilt
Moved this week
Latest in RNA Interference and Gene Delivery
Newest first · last 60 days
CRISPR RNP-mediated genome editing achieves transgene-free modifications in woody plants but faces significant delivery and regeneration challenges, especially in species like bamboo.
- Open access
- 21 cites
Synthetic pH-responsive membranolytic peptide induces immunogenic cell death, boosting immune checkpoint therapy efficacy in tumors with 50% enhanced response.
Innovative delivery systems and formulations are key to advancing mRNA therapeutics 2.0, enabling repeated administration and targeted organ delivery beyond the liver.
Proteolytic control of CRISPR-Cas systems achieves precise, tunable gene expression with reduced variability, enabling improved gene therapy for dosage-sensitive disorders.
- Open access
- 2 cites
Meta-analysis of melanoma miRNome reveals 24 diagnostic and 23 prognostic miRNA signatures that regulate metabolic plasticity and stress resistance in melanoma progression.
- Open access
- 2 cites
mRNA-encoded CD19-targeting T cell engager achieves complete B cell depletion and durable platelet recovery in refractory immune thrombocytopenia with minimal safety concerns.
- Open access
Multi-cycle reagent recycling in in vitro transcription and purification reduces raw-material costs by over twofold while maintaining RNA quality over five cycles.
- Open access
Codon-dependent translation of N1-ethylpseudouridine-modified mRNA reduces innate immunity while maintaining vaccine efficacy.
- Open access
Modified hm5C self-amplifying RNA enables over five weeks of sustained gene expression in mouse brain cells and more than 76 days in human brain slices.
- Open access
- 1 cites
Computational design methods have enabled the creation of optimized viral vectors, advancing gene therapy with significant improvements in vector properties.
- Open access
Hidden open reading frames in plasmids are present in about 6% of constructs, predominantly in the +2 frame, with some producing stable proteins like eGFP.
A novel lipid nanoparticle formulation, INTENT-2.1, effectively activates type I interferons and CD8(+) T cells to control tumors in cancer vaccines.
- Open access
pH-sensitive amino lipid-driven fusion via stalk-pore mechanism enhances endosomal escape of lipid nanoparticles, improving nucleic acid delivery efficiency.
- Open access
PRIME-VLP enhances prime editing efficiency by up to 2.9-fold across diverse targets using multiple sequential virus-like particle transductions.
- Open access
Follow this area in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1746
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4