AI-driven multimodal models improve prediction of recurrence and survival in liver cancer, surpassing single-modality approaches in accuracy.
- Open access
Journal of hepatology
Elsevier BV · Clinical Medicine · ISSN 0168-8278, 1600-0641
- Impact (2-yr)
- 2.5
- h-index
- 386
- Open access
- 21%
- Works
- 58.1K
- Papers this month
- 37
Rebuilt
Moved this week
Latest in Journal of hepatology
Newest first · last 60 days
Locoregional therapies in cholangiocarcinoma show promising 3-year overall survival rates up to 50%, especially when combined with systemic treatments.
Liver cancer surveillance faces limited support due to lack of randomized trial evidence, with false positives and low sensitivity impacting effectiveness.
- Open access
- 1 cites
Advances in surgical planning and molecular understanding have expanded the resectability of liver cancers, with a focus on hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
- 1 cites
Integrating systemic therapy earlier in liver cancer shows promising but uncertain benefits, with advances in hepatocellular carcinoma and biliary tract cancers.
- Open access
Primary liver cancer cases and deaths increased by over 55% globally from 2000 to 2023, reversing previous declines and highlighting urgent public health needs.
- Open access
Liver transplantation offers a highly effective curative option for primary liver cancers, with expanded eligibility through neoadjuvant strategies and biomarker-guided selection.
Immune checkpoint inhibitor combinations have become the standard first-line systemic therapy for HCC, significantly improving survival and response rates over previous treatments.
- Open access
Targeted therapies have significantly improved outcomes for specific subgroups of biliary tract cancer, with FGFR2 fusions and IDH1 mutations showing notable response rates.
Blood-based biomarkers show promise for early detection and management of liver cancer but require further validation in clinical settings.
Recent advances in liver cancer imaging have enhanced detection, characterization, and prognostication, with key developments in ultrasound, CT, MRI, PET, and computational analysis.
- Open access
- 1 cites
AI-driven multimodal models improve prediction of recurrence and survival in liver cancer, surpassing single-modality approaches in accuracy.
- Open access
Liver transplantation significantly improves survival in patients with severe ACLF, with a 21% case-fatality rate for ACLF-3 at one year, but high risk persists for those with five or six organ failures.
Resmetirom and semaglutide are recommended for treating non-cirrhotic MASH with fibrosis stages 2-3, with tailored use based on patient profiles and comorbidities.
Matched targeted therapy after chemoimmunotherapy failure improves survival in advanced biliary tract cancer, especially when administered in second line, with median OS reaching 24.8 months.
The multi-target blood test (mt-HBT) detects early-stage hepatocellular carcinoma with 66.7% sensitivity, outperforming ultrasound's 22.2%, in a large multicenter study of at-risk patients.
KIR+ CX3CR1+ CD8+ T cells driven by EBV peptides promote liver transplant tolerance, with 20% of recipients showing potential biomarkers for tolerance.
Young systemic factors, especially B-cell-derived lymphotoxin β, restore aged liver regeneration by inducing transient hepatocyte reprogramming via LTβ/LTBR signaling, with a 70% regeneration boost in mice.
Follow Journal of hepatology in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1746
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4