Regression of liver cirrhosis.

Cirrhosis is a dynamic, modifiable disease state in which sustained aetiological control can induce meaningful architectural remodelling, but regression often leaves residual vascular dysfunction and oncogenic risk.

• Why it matters: Cirrhosis prevalence and mortality are rising globally, increasing chronic healthcare burden, recurrent hospitalisation, and liver transplantation needs, while advanced disease has been viewed as fixed end-stage.
• What they did: The work synthesizes evidence that single-cell and spatial analyses reveal a heterogeneous fibrotic niche shaped by context-specific fibrogenic, immune, and vascular phenotypes, and notes that conventional histological endpoints have limited sensitivity.
• The result: Structural improvement can provide measurable prognostic benefit, yet regression does not restore complete tissue homeostasis, implying that effective therapies and precise measurement tools are still needed.

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