Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 2 cites
Neuroinflammation and Neurodegeneration Mechanisms
Moving in bioRxiv, Cellular & molecular immunology, eLife, Immunity, Nature Genetics, Neuron.
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Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
Microglia exhibit diverse activation states and cellular subpopulations, enabling dual neuroprotective or neurotoxic roles in neuroinflammatory conditions.
- Open access
- 14 cites
A disease-associated microglial subtype with elevated GPNMB expands with Alzheimer's pathology and depends on TREM2 for neuroprotection.
- Open access
- 20 cites
Sibling-derived microglia comprise up to 52% of microglial cells in marmoset brains, highlighting extensive hematopoietic chimerism within neural tissue.
- Open access
- 6 cites
Latest in Neuroinflammation and Neurodegeneration Mechanisms
Newest first · last 60 days
A human iPSC-derived spheroid model reveals that remyelinated axons have thinner myelin sheaths after injury, advancing understanding of human myelin repair mechanisms.
- Open access
Oligodendrocytes actively support CNS function and contribute to disease, with their heterogeneity influencing roles across development, aging, and pathology.
AI-based analysis of over 6 million nuclei reveals specific cell subpopulations linked to diverse Alzheimer's disease phenotypes.
- Open access
- 1 cites
TRAM enables receptor-free myddosome formation, sustaining hours-long NF-κB activation and inflammatory gene expression in TLR signaling.
- Open access
Coenzyme A activates TLR4 and boosts IL-4-driven macrophage activation via MyD88, revealing a new metabolic pathway influencing immune responses.
- Open access
PLA2G2D in tumour-draining lymph nodes acts as a novel immune checkpoint that suppresses anti-tumour T cell responses, with inhibition reducing tumour growth in melanoma models.
- Open access
Gastrointestinal infections induce long-lasting, antigen-specific memory CD4(+) T cells in the brain and meninges, with up to 80% of dural T cells being gut-derived.
- Open access
Impaired bone marrow myelopoiesis driven by IFN-I response limits monocyte brain homing and accelerates Alzheimer's disease progression in mouse models and patients.
Trogocytosis-related CLDN18.2 impairs CD8(+) T cell cytotoxicity and promotes pancreatic cancer progression by degrading β-catenin and inducing immune senescence.
- 2 cites
Single-cell resolution spatial isoform sequencing reveals cell-type-specific isoform variability in multiple brain cell types, with over 450 million barcodes analyzed.
- Open access
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