Distinct functional connectivity gradients reveal that aging and Alzheimer's disease alter separate major brain communication pathways, with AD affecting sensory-association and aging impacting representation-executive axes.
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Nature Neuroscience
Nature Portfolio · Neuroscience · ISSN 1097-6256, 1546-1726
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A human iPSC-derived spheroid model reveals that remyelinated axons have thinner myelin sheaths after injury, advancing understanding of human myelin repair mechanisms.
- Open access
CLOK enables precise multicolor labeling of neurons by birthdate, revealing distinct maturation trajectories in zebrafish visual and motor systems.
- Open access
Hippocampal neurons encode semantic information with complex, context-dependent patterns, showing strong correlation with GPT-2 embeddings and semantic distances.
Anesthesia induces a conserved neural state across species, characterized by shorter timescales and reduced inter-regional synchrony, observed in humans, primates, rodents, fish, and nematodes.
- Open access
- 1 cites
High-resolution electrocorticography reveals distinct yet interconnected neural dynamics for speech imagery and articulation, with median decoding accuracy over 80%.
- Open access
Neuroscience faces a critical challenge balancing open data sharing and national data sovereignty, risking slowed innovation and increased global inequities.
Massively parallel reporter assay reveals 918 regulatory variants linked to human cortical structure, with over half showing allelic effects and some being condition-dependent.
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Tibial bone compression enhances brain recovery after injury by activating osteocyte PIEZO1, increasing survival and promoting neuronal regeneration in mice and pigs.
Reciprocal excitatory connections between V1 and LM create a dynamic consensus mechanism that stabilizes consistent activity patterns in the neocortex.
- Open access
Reduced serotonin neuron activity in the dorsal raphe during pregnancy drives food-craving-like behavior in mice, with SK3 ion channels playing a key role.
Two distinct neural ectoderm progenitors independently generate the forebrain/midbrain and hindbrain regions in mouse and human development.
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Hippocampal astrocytes generate time-compressed calcium sequences during learning and recall, resembling neuronal time-cell activity, in the dorsal CA1 region of mice.
Cerebellar input streams encode dopamine rewards with both predictive and instructive signals, influencing motivated behavior in mice.
Intracranial recordings reveal that medial and lateral orbitofrontal cortex exhibit opposing activity patterns during approach-avoidance decisions in humans.
Overlapping fear-related representations in vCA1 enable rapid memory switching, with vCA1 showing greater overlap and faster reinstatement than dCA1 during fear retrieval.
Neural signals from a single cortical implant enable simultaneous decoding of speech and gestures, improving communication options for people with paralysis.
- Open access
- 1 cites
Tau pathology in the human frontal lobe is linked to impaired slow-wave propagation and memory decline, with significant disruptions in traveling slow waves associated with Alzheimer’s disease.
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