Sibling chimerism among microglia in marmosets.
- Open access
- 6 cites
Sibling-derived microglia comprise up to 52% of microglial cells in marmoset brains, highlighting extensive hematopoietic chimerism within neural tissue.
- Why it matters: Understanding whether chimerism influences brain cell populations is crucial for insights into immune cell contributions to brain function and disease, especially in species with natural chimerism.
- What they did: Single-cell RNA sequencing of multiple tissues from marmosets identified sibling-derived cells using transcribed SNPs, revealing that chimerism in brain tissue is restricted to microglia and macrophages.
- The result: The findings demonstrate that microglial chimerism varies across brain regions and is driven solely by hematopoietic lineage cells, providing a model to study gene and environment effects on microglia.