Microglia exhibit diverse activation states and cellular subpopulations, enabling dual neuroprotective or neurotoxic roles in neuroinflammatory conditions.
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Cellular & molecular immunology
Springer Nature · Cell & Molecular Biology · ISSN 1672-7681, 2042-0226
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γδ and αβ CAR-T cells show similar cytotoxicity but differ significantly in metabolic and signaling pathways, with γδ cells exhibiting lower glycolytic and oxidative capacities.
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NLRP3 inflammasome integrates innate immune signaling and cell death pathways, coordinating inflammatory responses and pyroptosis during infections and inflammation.
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HnRNPK limits memory B-cell and plasma cell differentiation, maintaining germinal center B-cell output by regulating transcription and metabolism.
p97 is essential for late-stage thymocyte positive selection, with its loss causing a severe blockade in CD8+ lineage commitment and thymocyte development.
Disrupting the FOXP3-T-bet interaction impairs Treg stability and promotes IFN-γ-driven Th1 inflammation in IPEX syndrome, with a small molecule restoring this interaction.
ABTB1 functions as an E3 ubiquitin ligase that suppresses Th17 cell differentiation by promoting STAT3 degradation, reducing autoimmune inflammation.
Metabolic reprogramming in lymphocytes, including increased glycolysis and mitochondrial dysfunction, drives T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
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Plakophilin 1 (PKP1) suppresses keratinocyte innate immune responses by sequestering RNA helicases, preventing excessive inflammation in healthy skin cells.
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MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and degradation, limiting inflammatory responses and disease severity.
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis severity by enhancing ECM remodeling and protecting enteric neurons, with a 50% decrease in inflammation.
IL-17D reprograms CD93(+) antigen-presenting cells in glioblastoma, extending survival by substantial reorganization of the tumor immune environment.
Platelet-derived serotonin activates an epigenetic pathway involving TGM2 and H3Q5Ser to promote macrophage alternative activation in airway inflammation, with 50% reduction in disease severity when inhibited.
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αTIGIT-guided IL-15 mimetics significantly enhance antitumor immunity, achieving potent effects without systemic toxicity in vivo.
γδ and αβ CAR-T cells show similar cytotoxicity but differ significantly in metabolic and signaling pathways, with γδ cells exhibiting lower glycolytic and oxidative capacities.
NLRC3 enhances antitumor immunity by inhibiting M-MDSC infiltration and function through a STING-dependent pathway, reducing tumor growth.
NADPH oxidases (NOXs) are key regulators of immune, metabolic, and environmental signals, with recent studies revealing their structures, regulatory mechanisms, and roles in disease, especially in immune and tumor contexts.
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Radiotherapy induces CD200(+) tumor-associated macrophages via STING pathway, which suppress eosinophil-mediated antitumor immunity in hepatocellular carcinoma.
Tumor cell-released autophagosomes (TRAP) program inflammatory CAFs to promote immune exclusion via C3a, with a 96% accuracy in distinguishing breast cancer patients.
The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
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