The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.
- Open access
NLRP3 inflammasome integrates innate immune signaling and cell death pathways, coordinating inflammatory responses and pyroptosis during infections and inflammation.
- Why it matters: Understanding how NLRP3 interacts with other immune and cell death pathways is crucial for developing targeted therapies for infectious and inflammatory diseases, yet these complex networks are not fully elucidated.
- What they did: The authors review recent advances in molecular mechanisms, including shared signaling components, organelle dynamics, and posttranslational modifications, based on studies of NLRP3's interactions with Toll-like receptors, cGAS-STING, RIG-I/MDA5-MAVS, and other inflammasomes.
- The result: This synthesis highlights how interconnected signaling networks influence disease progression and suggests new avenues for therapeutic intervention by targeting inflammasome-related pathways.