Deubiquitinases at the crossroads of T-cell immunity and tumor immune evasion.

Deubiquitinases (DUBs) are positioned as key regulators at the interface of T-cell immunity and tumor-intrinsic immune evasion, shaping ubiquitin signaling that affects both compartments.

• Why it matters: Immune checkpoint blockade often fails in many patients, creating a need for additional targets that can strengthen antitumor T-cell responses and overcome tumor immune escape.
• What they did: This review synthesizes accumulating evidence on how DUBs, by removing ubiquitin from substrate proteins, dynamically tune protein stability, localization, activity, and interactions relevant to T-cell function and tumor immune evasion.
• The result: The authors argue that considering DUBs across both T-cell immunity and tumor-intrinsic evasion can guide therapeutic strategies targeting DUBs along this axis.

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