Programmable nanoassembly cycles restore bacterial redox and energy balance by linking supramolecular transformations with genetic responses.
- Open access
Nature Chemical Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 1552-4450, 1552-4469
- Impact (2-yr)
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Latest in Nat Chem Biol
Newest first · last 60 days
Metagenomic enzymes targeting stable bonds in plastics show promise but currently lack sufficient activity for efficient nylon and polyurethane depolymerization.
Polymer-based synthetic receptors achieve site-specific enrichment of phosphopeptide isomers, resolving adjacent phosphorylation sites with high precision in complex proteomes.
Coliphage HY126 encodes a novel dual cytosine modification system involving hydroxylation and diarabinofuranosylation, creating a unique DNA modification with two arabinofuranose units.
- 2 cites
Venetoclax-controlled DROP-CAR T cells effectively regulate tumor targeting and reduce off-tumor toxicity through dose-dependent cell-cell interaction modulation.
- Open access
- 2 cites
Noncanonical cytochrome P450 enzymes lacking the conserved cysteine are widespread, with 20 distinct families identified in diverse microbial genomes.
Disruption of ROS rhythmicity through dual inhibition of IDO1 and AhR extends survival in cancer models, revealing a new therapeutic approach targeting tumor oxidative balance.
- 1 cites
Artificial metalloenzymes can be engineered to function effectively in complex biological environments, including cell lysates, surfaces, and intracellular spaces, overcoming previous limitations.
A chemigenetic HaloRasAR biosensor enables precise live-cell tracking of endogenous Ras activity with subcellular resolution.
Nuclear stress-induced modification of NCBP1 at cysteine 436 causes alternative splicing of over 250 genes, including S6 kinase, leading to translation inhibition.
- Open access
- 1 cites
Monovalent degraders can recruit two E3 ligases simultaneously to degrade SMARCA2/4, with tunable dependency on DCAF16 or FBXO22.
- Open access
- 2 cites
A novel small-molecule inverse agonist, HEP-50768, effectively targets MRGPRX4 and suppresses cholestatic itch in preclinical models.
- 1 cites
Nuclear OXCT1 reduces histone β-hydroxybutyrylation at MHC-I loci, decreasing immune gene transcription and impacting hepatocellular carcinoma response to immunotherapy.
CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase by inducing binding to GID4 in vitro and in cells.
- 1 cites
PRADA enables in vivo proximity labeling of proteins and RNAs across multiple organisms, revealing RNA folding as a key regulator of mitochondrial gene expression.
SRSF1 regulates nucleolar cap pH to maintain nucleolar integrity, with loss impairing pH homeostasis and recovery after stress.
Sequence-selective small molecules can precisely halt translation by targeting specific RNA or peptide sequences in eukaryotic cells.
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