Nature Chemical Biology · 1 Oct 2026 · Journal Article

Recruiting without destroying.

Pieńkowska, Nowak

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MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency.
Cell Reports · 29 Sept 2026 · Journal Article
Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
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Androgen-PDH axis modulates sexual dimorphism of mitochondrial respiration in visceral fat.
Cell Reports · 22 Sept 2026 · Journal Article
Androgen-AR signaling suppresses mitochondrial respiration in visceral fat by downregulating Pdhb, contributing to sex differences in fat accumulation and metabolic risk.
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ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.10.675409
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