Peroxisome Proliferator-Activated Receptors
Moving in Cell Reports, bioRxiv, eLife, Gut, Journal of Cell Biology, Journal of hepatology, Nature Chemical Biology, Nature Communications.
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Latest in Peroxisome Proliferator-Activated Receptors
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Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
- Open access
Androgen-AR signaling suppresses mitochondrial respiration in visceral fat by downregulating Pdhb, contributing to sex differences in fat accumulation and metabolic risk.
- Open access
PISD-LD functions as a molecular switch, promoting fatty acid transfer to mitochondria while inhibiting lipophagy, thereby regulating energy production during starvation.
SETD6 methylates PPARγ at K170, creating a positive feedback loop that promotes lipid accumulation in liver-derived cells.
- Open access
Stearoyl-CoA desaturases are essential for intestinal stem cell function, with their inhibition reducing stem cell proliferation and impairing tissue regeneration in mice.
- Open access
Hepatic ACSF3 regulates rhythmic lysine-malonylation and daily liver metabolism, with knockdown disrupting glucose and lipid homeostasis in mice.
- Open access
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Moving areas, week to 3 Oct 2026
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