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PPAR/RXR dysregulation involved in hepatic lipid accumulation in HFPO-TeA-exposed zebrafish: Insights from multi-omics and spatial imaging.
Environmental research · · Journal Article
Shi, Chen + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
HFPO-TeA exposure in adult zebrafish causes steatosis-like hepatic injury linked to a PPAR/RXR dysregulation pattern, including pparg upregulation and RXR down-regulation.
- Why it matters: Emerging PFAS alternatives like HFPO-TeA are increasingly used, yet their aquatic liver toxicity and underlying lipid-regulatory mechanisms remain unclear.
- What they did: Adult zebrafish were assessed using histopathology, non-targeted lipidomics, transcriptomics, and MALDI-TOF-MSI spatial lipid imaging; lipidomics quantified 4681 lipid species across 43 classes.
- The result: The study found triglycerides upregulation and lysophosphatidylcholines downregulation, with transcript changes supporting a shift toward fatty-acid synthesis and triglyceride storage, and MALDI-TOF-MSI showing heterogeneous lipid redistribution in liver tissue.
The findingWhy it mattersWhat they didThe result
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