Atg23 prevents inappropriate fusion of Atg9 vesicles during autophagosome formation in yeast, ensuring proper membrane delivery for autophagy.
- Open access
- 1 cites
Autophagy in Disease and Therapy
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Lysosomal metabolism is essential for pancreatic ductal adenocarcinoma survival, with pathways supporting tumor growth and immune evasion despite limited success of current therapies.
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Lysosomal lipid and protein changes in the aging brain show increased myelin components and disrupted sphingolipid breakdown, especially in microglia, indicating dysfunction.
- Open access
AMBRA1 allosterically activates NLRP3 by destabilizing its autoinhibited conformation, promoting inflammatory responses in mouse disease models.
Disruption of ROS rhythmicity through dual inhibition of IDO1 and AhR extends survival in cancer models, revealing a new therapeutic approach targeting tumor oxidative balance.
- 1 cites
Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating chaperone-mediated autophagy and promoting tumor growth and viral persistence.
LAPTM4A enhances mTORC1 signaling, promoting pathological cardiac hypertrophy in mice and humans, with deletion reducing hypertrophy and fibrosis.
Inhibiting autophagy with ATG7 silencing nanoparticles enhances radiotherapy effectiveness in high-grade mutant IDH1 gliomas, leading to tumor regression and long-term survival.
- Open access
Cholesterol is essential for maintaining lysosomal function during mitochondrial clearance, with significant effects observed in cellular health.
- Open access
Proteome changes during replicative senescence are highly coordinated, with widespread chromatin protein depletion and increased mitochondrial insolubility, affecting cellular function.
- Open access
Autophagy is essential for maintaining high endothelial venule identity and function during inflammation, with deficiency reducing lymphocyte homing by 50%.
- Open access
PISD-LD functions as a molecular switch, promoting fatty acid transfer to mitochondria while inhibiting lipophagy, thereby regulating energy production during starvation.
PIKfyve regulates ER morphology and dynamics by modulating lysosome-ER contacts, with its inhibition causing less reticulated ER and impaired motility.
Mitochondrial calcium influx via MCU in dopaminergic neurons drives drug-specific dopamine release, enabling addiction behaviors without affecting natural rewards.
Tumor cell-released autophagosomes (TRAP) program inflammatory CAFs to promote immune exclusion via C3a, with a 96% accuracy in distinguishing breast cancer patients.
CaSAP8 and CaDSK2a form a negative feedback loop that dynamically regulates thermotolerance in pepper, with CaSAP8 enhancing and CaDSK2a attenuating heat stress responses.
- Open access
- 1 cites
TM184C, a conserved GPCR-like protein, regulates intercellular exchange and autophagy by localizing to vesicles and forming intercellular connections in human cells.
- Open access
- 1 cites
CaMACPF1 and CaMACPF6 enhance hypoxia tolerance in pepper by modulating jasmonate and auxin pathways, with overexpression improving plant endurance under stress.
- Open access
Atg23 prevents inappropriate fusion of Atg9 vesicles during autophagosome formation in yeast, ensuring proper membrane delivery for autophagy.
- Open access
- 1 cites
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