Emeritus professors could significantly enhance academia and society if provided with adequate support, which is currently hindered by ageism.
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EMBO Reports
Springer Nature · Cell & Molecular Biology · ISSN 1469-221X, 1469-3178
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Scarcity of resources enhances intellectual discipline and ingenuity, as demonstrated by how limited access fosters innovative research approaches.
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Implementing replication of key experiments in scientific publishing is essential to address the ongoing replication crisis and improve research reliability.
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Lipid droplets induce aberrant alpha-synuclein phase separation, disrupting mitochondrial function and energy balance in Parkinson's disease models.
- Open access
- 2 cites
Human ZBP1 induces cell death more potently than mouse ZBP1, relying on RIPK1 and all three RHIM domains, with distinct signaling mechanisms.
- Open access
- 3 cites
Type I interferons inhibit NLRP1-driven PANoptosis by reducing NLRP1 expression through a TLR4-TRIF-IRF3 signaling pathway.
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Phosphoglycerate kinase 1 (PGK1) acts as a co-adaptor with the AP2 complex, enhancing cargo recognition and promoting endocytosis independently of its enzymatic activity.
- Open access
Greatwall kinase controls cytokinesis and cell cycle in AML cells via a novel pathway independent of ENSA-PP2A-B55, revealing a unique regulatory mechanism.
- Open access
FBXL21 controls diurnal proteostasis in skeletal muscle by degrading DNAJB6 and its client proteins, with mutations conferring resistance and disrupting protein balance.
- Open access
α-Synuclein reduces triglyceride levels and disrupts lipid droplet and mitochondrial structure, linking lipid metabolism to neurodegenerative toxicity in C. elegans.
- Open access
Host-derived TNF-α binds to mosquito Wengen receptor, increasing malaria transmission by 50% through immune suppression mechanisms.
UHRF1 overexpression in zebrafish liver induces diverse senescent states with distinct Tp53 dependencies, revealing epigenetic influences on senescence phenotypes.
PTEN-L suppresses GSDME-dependent pyroptosis by dephosphorylating and inactivating Parkin, preventing mitochondrial-driven inflammatory cell death.
Cancer cells inactivate the mitochondrial tumor suppressor LACTB through enhanced autoproteolysis mediated by MRPS34 in breast cancers.
- Open access
BBX preserves mammalian brain development by inhibiting the p53-p21-RB pathway, preventing premature cell-cycle exit and senescence in neural stem cells.
LC3B forms approximately 150 nm nanoclusters on autophagosomes, crucial for autophagy functions and pathogen clearance.
Enhanced assembly of mitochondrial respiratory supercomplexes during mitosis is essential for accurate cell division and tumor growth, with a 2.5-fold increase observed in cancer cells.
- Open access
Reduced nascent rRNA synthesis drives nucleolar reorganization under stress, altering sub-structures and biophysical properties in Homo sapiens cells.
- Open access
VGLL4 promotes MAFLD progression by enhancing PDK4 transcription, with overexpression causing steatosis and knockout offering protection in mice.
- Open access
Upregulation of AK7 in ACC glutamatergic neurons drives chronic inflammation pain via the ACC-VTA circuit in male mice.
TRIM62 enhances influenza A virus entry by modulating WASH-dependent endosomal trafficking, promoting viral internalization through retromer regulation.
- Open access
Coenzyme A activates TLR4 and boosts IL-4-driven macrophage activation via MyD88, revealing a new metabolic pathway influencing immune responses.
- Open access
Light-induced Aurora A clustering can reconstitute functional spindle assembly in human cells, bypassing traditional centrosome components, with 200 proteins involved in natural assembly.
Pde1b is essential for immune responses by regulating cyclic nucleotide signaling in cDC1 and macrophages, with its loss impairing bacterial clearance and T cell activation.
Selection favors cost-ordered adaptive mutational paths in Escherichia coli depending on stress magnitude, with distinct mechanisms activated at different paraquat levels.
GPR84 is essential for leukocyte uropod de-adhesion during extravasation, with deficiency causing flawed detachment in mice and Drosophila, impairing immune cell migration.
High circulating LDL cholesterol enhances SARS-CoV-2 replication through ORF3a-mediated cholesterol uptake, especially in the Beta variant, potentially worsening COVID-19 severity.
Disordered domains in transcription factors challenge traditional views, revealing roles beyond DNA binding and transcriptional activation, with occupancy not always linked to gene expression.
Loss of cGAS in killifish reduces age-related cellular senescence and transcriptional aging signatures but does not extend lifespan.
- Open access
Aurora A kinase enhances inflammasome activation, increasing inflammation and bacterial survival in antibiotic-resistant Staphylococcus aureus infections.
- Open access
uORF-mediated repression of CAK1 reduces Cak1 levels and Cdc28 activation in yeast under low-nutrient conditions, impacting cell cycle regulation.
KCC2a isoform acts as a developmental switch, inhibiting KCC2b in early neurons and stabilizing it in mature cortical neurons, crucial for synaptic inhibition.
Vimentin loss impairs DNA repair and increases cancer cell survival under genotoxic stress, especially in glioblastoma cells, by disrupting nuclear mechanics.
- Open access
CpG methylation increases DNA stiffness, weakens nucleosome wrapping, and enhances chromatin condensate density, promoting heterochromatin organization across multiple scales.
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4