PI4K2A promotes cancer cell motility by regulating c-MET recycling.

PI4K2A promotes non-small cell lung cancer cell motility by directing endocytosed c-MET to RAB14-positive recycling endosomes, enhancing MET recycling and activation.

• Why it matters: Metastasis depends on dynamic control of cell-surface proteins, yet how endocytic recycling tunes receptor abundance and motility in NSCLC is not fully defined.
• What they did: Using cancer cell surfaceome profiling, the study identified PI4K2A as a regulator of surface protein levels and tested how PI4K2A–MET interactions route MET to RAB14-positive recycling endosomes.
• The result: PI4K2A’s pro-recycling and pro-migratory effects are independent of its kinase activity, implying a kinase-independent PI4K2A role in regulating the cancer cell surfaceome.

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