The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis.

The AMIGa complex is essential for proper assembly of cytochrome c oxidase and ATP synthase, with Aim11 playing a key role in mitochondrial respiratory function.

• Why it matters: Understanding the assembly of these complexes is crucial because defects can impair energy production, contributing to mitochondrial diseases; however, the specific factors involved remain unclear.
• What they did: Researchers characterized Aim11's role by analyzing a null mutant, revealing reduced respiratory growth and complex activity, and identified the AMIGa complex comprising Aim11, Mtc3, Iai11, and Gep7.
• The result: Findings show Aim11 interacts with assembly intermediates and the Atco complex, highlighting its importance in biogenesis and suggesting the human orthologue TMEM242 may have a similar function.