Comparative analysis reveals 8,619 mitochondrial proteins across eight species, uncovering conserved families and potential drug targets in eukaryotic pathogens.
- 7 cites
Mitochondrial Function and Pathology
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Latest in Mitochondrial Function and Pathology
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Excised leaf samples in Arabidopsis exhibit more photosystem II damage and less thylakoid restructuring under high light than intact plants, impairing repair processes.
- Open access
The human Mic60-Mic19 subcomplex forms a dynamic tetrameric structure that acts as a diffusion barrier at mitochondrial crista junctions, with a key role in mitochondrial regulation.
- Open access
Cancer cells inactivate the mitochondrial tumor suppressor LACTB through enhanced autoproteolysis mediated by MRPS34 in breast cancers.
- Open access
Enhanced assembly of mitochondrial respiratory supercomplexes during mitosis is essential for accurate cell division and tumor growth, with a 2.5-fold increase observed in cancer cells.
- Open access
NAD+ precursor treatment improves cardiac function but impairs erythroid maturation in mitochondrial progeria mice, revealing tissue-specific effects.
- Open access
Multi-organelle signatures identified distinct cell states and metabolic adaptations in liver and pancreas tissues, revealing complex intra-zonal heterogeneity and stress responses.
Mutations in the intracellular subdomain of LRRC8A cause constitutive activation of VRAC channels, highlighting its role as a key regulatory hub.
- Open access
- 1 cites
PADI1 and PADI3 promote resistance to KRAS inhibitors by sustaining mitochondrial adaptation in KRAS-driven tumors.
- Open access
Loss of rice ZEP1 disrupts homologous recombination, causing asynapsis and chromosome fragmentation, highlighting its crucial role in meiotic genome integrity.
- Open access
Intercellular mitochondrial transfer via tunnelling nanotubes enables mitochondrial regeneration and rescue in cells with import dysfunction, involving distinct degradation pathways for different mitochondria.
- Open access
Mitochondrial calcium influx via MCU in dopaminergic neurons drives drug-specific dopamine release, enabling addiction behaviors without affecting natural rewards.
Cardiolipin deficiency in mitochondria impairs electron transport chain function and causes steatohepatitis in mice and humans.
- Open access
- 1 cites
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