The abstract is read at the publisher; the summary is JClub's.
Vitamin B2-dependent FlavProt is an injury-sensitive network in MASLD, and flavin-cofactor replenishment mitigates FlavProt-linked dysregulation in human hepatocytes under stress.
- Why it matters: Drug discovery for MASLD is hindered by network effects, and existing interactome analyses struggle to contextualize compounds efficiently across disease-relevant biology.
- What they did: MetaLiver integrates a MASLD-specific knowledge graph with progression-resolved bulk and hepatocyte single-cell data, cutting computing time 18.8-fold; iPSC-derived and primary human hepatocytes were used for validation.
- The result: A FlavProt expression score correlates with poor outcomes in retrospectively stratified MASLD patients, and AIFM2 deficit-driven hepatocyte death is controllable by flavin-cofactor availability.
The findingWhy it mattersWhat they didThe result
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