Research area · week to 3 Oct 2026

Cell death mechanisms and regulation

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Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis.
Neuron · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42025167
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Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1.
EMBO Reports · 1 Sept 2026 · Journal Article
Human ZBP1 induces cell death more potently than mouse ZBP1, relying on RIPK1 and all three RHIM domains, with distinct signaling mechanisms.
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Latest in Cell death mechanisms and regulation

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Integrated in vitro multi-endpoint framework for assessing 6PPD-Quinone cytotoxicity in fish and mammalian cell lines.
Environmental pollution · 1 Oct 2026 · Journal Article
Fish-derived cell lines exhibit greater susceptibility to 6PPD-Q toxicity than mammalian cells, with pNPA values indicating higher phenotypic perturbations across five cell types.
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https://jclub.com.au/a/42349825
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Mechanisms, regulation and clinical relevance of necroptosis.
Nature Reviews Molecular Cell Biology · 1 Oct 2026 · Review
Necroptosis involves two distinct subtypes, extrinsic and intrinsic, with over 50% of pathways triggered by membrane receptors or intracellular sensors.
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Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.
eLife · 30 Sept 2026 · Journal Article
Gβ3γ3 acts as a critical positive allosteric modulator, reorienting PLCβ3 to enhance activation and PI(4,5)P2 hydrolysis at the plasma membrane.
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Mitochondrial priming in human germ cell tumors is dependent on MCL1 and BCL2L1
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.752028
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Targeting RAS for Pancreatic Cancer Interception.
Cancer Discovery · 22 Sept 2026 · Journal Article
Targeting RAS mutations offers promising strategies for intercepting pancreatic cancer at its precancerous stage.
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Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation.
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.14.670414
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RAS seals fate in AML besieged by FLT3 and BCL2 inhibitors.
Blood · 17 Sept 2026 · Editorial
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https://jclub.com.au/a/42752833
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Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis.
eLife · 11 Sept 2026 · Journal Article
NINJ2 maintains lysosomal membrane integrity to prevent ferroptosis, with loss increasing susceptibility by 2.5-fold in cell models.
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Identification and SAR optimization of FBXO22-mediated TEAD Targeted Glue degraders
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.719895
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Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis.
Neuron · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42025167
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Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1.
EMBO Reports · 1 Sept 2026 · Journal Article
Human ZBP1 induces cell death more potently than mouse ZBP1, relying on RIPK1 and all three RHIM domains, with distinct signaling mechanisms.
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- 3 cites
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https://jclub.com.au/a/42436309
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Cuproptosis promotes antitumour immunity.
Nature Reviews Cancer · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42458013
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DNA Repair Exhaustion Activates Orthocaspase-Mediated Cell Death and Promote Inclusive Fitness of Cyanobacterial Population Under Abiotic Stress.
Plant, Cell & Environment · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42304937
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Functional characterization of CiCIPK8 and CiCIPK11 reveals their roles in osmotic stress via CBL-CIPK signaling in pecan (Carya illinoinensis).
Plant Physiology and Biochemistry · 1 Sept 2026 · Journal Article
CiCIPK8 and CiCIPK11 enhance osmotic stress tolerance in pecan by activating antioxidant defenses and osmolyte accumulation, with significantly improved seed germination and root growth under stress.
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Caspase-3 cleaves CYLD to restrict interferon signaling during mitochondrial apoptosis.
EMBO Reports · 1 Sept 2026 · Journal Article
Caspase-3 cleaves CYLD at a novel site to limit interferon signaling during mitochondrial apoptosis, reducing inflammation and promoting immune silence.
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https://jclub.com.au/a/42458071
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Proteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice.
EMBO Journal · 1 Sept 2026 · Journal Article
Proteolytic activation of caspase-3 and caspase-7 is essential for distinct physiological processes in mice, with activation controlling different functions in adult tissues.
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https://jclub.com.au/a/42481806
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SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death.
Communications Biology · 31 Aug 2026 · Journal Article
Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis, causing lysosomal damage that triggers inflammatory cell death in SARS-CoV-2.
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https://jclub.com.au/a/42675129
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Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.13.603409
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Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis.
Blood · 20 Aug 2026 · Journal Article
Deletion of cFLIP in B cells prevents diffuse large B-cell lymphoma development in mice, highlighting its essential role in lymphoma pathogenesis.
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https://jclub.com.au/a/42024475
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Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
bioRxiv · 12 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.07.687251
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