Cell Reports Medicine

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Adoptive transfer of stem-like CD8+ T cells followed by intravenous vaccination prevents immune exclusion in the tumor microenvironment and reprograms tumor cells to upregulate IFN signaling programs.

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XPO5 is linked to advanced prostate cancer progression by promoting ferroptosis resistance through MITF nuclear export and suppression of ACSL4 transcription.

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Favorable neoadjuvant immunochemotherapy (NICT) in esophageal squamous cell carcinoma is linked to preserved CXCL13+ PD-1+ CD8+ T cells and post-treatment enrichment of a progenitor-like CD8Tex_CXCR4 subset.

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Temporally gated MANAGE CAR-T cells using a FITC-sensing synNotch receptor reduce exhaustion and preserve stem-like phenotypes versus constitutive CAR-T in solid-tumor in vivo models.

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In-context learning for medical AI is a promising but immature way for large language models to adapt to new tasks via examples in prompts, without changing parameters.

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Ampicillin with probenecid in microbiota-humanized gnotobiotic mice is linked to death in pups whose gut microbiota includes ampicillin-resistant Enterobacteriaceae, with increased permeability and systemic microbial spread.

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A portable sliding annular in situ bioprinting (SAIP) system enables rapid, robust in situ fabrication of complete small-diameter tubular vascular grafts after scaffold dissolution.

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CD39/CD73 adenosinergic pathway activity is increased in human NSCLC tumor microenvironments, with preferential expression in lung adenocarcinomas linked to elevated PD-L1 and effector T cell infiltration.

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High intratumoral abundance of Bifidobacterium dentium is linked to poorer survival in colorectal cancer patients, and it accelerates CT26 and B16F10 tumor growth in mice.

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In the Framingham State Food Study (FS(2)) randomized feeding trial, varying carbohydrate-to-fat ratio during 20-week weight-loss maintenance did not change gut microbiome composition, despite diet-induced metabolic context.

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Propionate levels in plasma and paired stool samples are consistently linked to lower disease activity in pediatric-onset multiple sclerosis, with replication in an external cohort.

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In a multicenter real-world cohort of 606 bladder cancer (BLCA) patients, neoadjuvant immunotherapy is linked to dynamic TME evolution, including immunotherapy resistance marked by SERPINH1 and an excluded immune phenotype.

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Lipid-enriched senescent T cells are abundant across breast, colorectal, and lung cancers and actively reprogram tumor cells to drive growth, stemness, metastasis, and chemotherapy resistance.

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A systematic review of 35 MRI studies finds unimodal foundation models and multimodal vision-language models are most mature for neuroimaging diagnostic classification, with segmentation and outcome prediction showing promise.

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ESCCseeker, a peripheral blood mononuclear cell DNA methylation risk tool for esophageal squamous cell carcinoma in China, achieves AUCs up to 0.987 and enables triage.

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DVX-panH5Nx, a digitally immune-optimized mRNA vaccine, elicits broad HA neutralization and NA inhibition against globally diverse influenza A/H5Nx viruses, protecting mice and ferrets.

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SHIFT-engineered immunogen-sponge hydrogel based on Pluronic F127 reverses TIM-3-associated dendritic cell dysfunction in alveolar echinococcosis mouse models, restoring antigen presentation.

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Antigen-scaffold expansion of CRISPR-Cas9-engineered TCR T cells and anti-CD19 CAR T cells yields an average 69% (±22%) antigen-specific T cells after 14 days.

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Lipid transfer, load, metabolism, and cellular homeostasis are positioned as upstream drivers of pathology across neurodegenerative diseases, reframing therapeutic development beyond protein aggregation.

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Retrospective study designs dominate translation-relevant evidence in medical AI, with 158 of 247 original studies (64.0%) relying on retrospective data in clinical and translational journal publications.

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A harmonized atlas of 7,612 bulk breast cancer transcriptomes from 22 datasets resolves malignant transcriptional states, including stem-like and neuroendocrine-differentiated subtypes.

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Programmed cell death research is being reframed around translating underlying mechanisms into effective therapies, with a focus on future directions and key translational challenges.

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Y31-20K-KU, an IL-2 immunoconjugate, selectively expands regulatory T cells while suppressing effector cells, restoring immune homeostasis and improving mouse models of chronic colitis and collagen-induced arthritis.

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MorphX, an interpretable deep-learning framework, predicts survival in hepatocellular carcinoma (HCC) and lung adenocarcinoma (LUAD) with concordance indices of 0.775–0.799 in discovery cohorts.

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A TNBC digital twin framework predicts treatment responses and links mutational and transcriptional biomarkers to clinical outcome in PARTNER, a randomized trial of platinum chemotherapy ± PARP inhibitors.

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Uncertainty-aware AI can flag unreliable outputs in clinical workflows, but uncertainty estimates alone do not establish safety without validation against relevant errors and linked actions.

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A single intravenous dose of T-IDLE STCE in a murine Sjögren's syndrome-associated dry eye model induces deep, time-limited depletion of plasmablasts and plasma cells.

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AP/LC CXCR4 engineered hepatocyte-based micronanorobots deplete intratumoral lactate and, with radiotherapy, sustain DNA damage in radioresistant colorectal and metastatic cervical cancer models.

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CTPS1 inhibition in fully MHC-mismatched and haploidentical hematopoietic stem cell transplantation models completely blocks aGVHD induction, linked to significantly reduced alloreactive effector T cell expansion.

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Eight FDA-approved AAV therapies, including four for CNS disorders, show AAV gene transfer can change the course of devastating neurological diseases while key barriers remain.