The abstract is read at the publisher; the summary is JClub's.
ESCCseeker, a peripheral blood mononuclear cell DNA methylation risk tool for esophageal squamous cell carcinoma in China, achieves AUCs up to 0.987 and enables triage.
- Why it matters: Endoscopy-based screening is hard to scale, and existing biomarkers limit efficient selection of who should undergo invasive testing.
- What they did: In a two-stage multicenter study, genome-wide methylation profiling identified markers, and machine learning built a model using eight differentially methylated positions plus age, gender, SCC-Ag, and CYFRA21-1.
- The result: Using a predefined cutoff in a prospective multicenter cohort, endoscopy was reduced from 25.02 to 4.78 per person while avoiding 83% of unnecessary procedures and preserving >90% detection sensitivity.
The findingWhy it mattersWhat they didThe result
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