A sliding annular in situ bioprinting strategy for rapid and robust fabrication of small-diameter vascular grafts.

A portable sliding annular in situ bioprinting (SAIP) system enables rapid, robust in situ fabrication of complete small-diameter tubular vascular grafts after scaffold dissolution.

• Why it matters: In situ vessel reconstruction is promising for urgent organ repair, but in situ printing of blood vessels is still limited, especially for practical emergency use.
• What they did: The SAIP platform uses a ring-shaped printhead with multiple nozzles to deposit rapidly crosslinking, strongly adhesive bioink onto a sacrificial scaffold bridging blood vessel ends.
• The result: Successful carotid artery repair demonstrates feasibility, supporting clinical potential for in situ vascular reconstruction during emergency interventions.

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