The abstract is read at the publisher; the summary is JClub's.
High intratumoral abundance of Bifidobacterium dentium is linked to poorer survival in colorectal cancer patients, and it accelerates CT26 and B16F10 tumor growth in mice.
- Why it matters: Intratumoral microbiota can shape cancer outcomes, but the specific tumor-associated microbes and their mechanisms are not well defined.
- What they did: The study identified B. dentium enriched in fecal samples from melanoma and CRC patients and present in human melanoma and CRC tissues, then tested live subgingival dosing in mouse tumor models and assessed invasion, Akt/ERK signaling, MMP3, and GABA–FOXA2–P-gp.
- The result: B. dentium invades tumor cells, induces MMP3 and Akt/ERK-driven proliferation, and increases resistance to key chemotherapeutics via GABA-mediated FOXA2-dependent P-gp upregulation.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.