The abstract is read at the publisher; the summary is JClub's.
AP/LC CXCR4 engineered hepatocyte-based micronanorobots deplete intratumoral lactate and, with radiotherapy, sustain DNA damage in radioresistant colorectal and metastatic cervical cancer models.
- Why it matters: Tumor lactate supports DNA repair and an immunosuppressive microenvironment, limiting radiotherapy effectiveness and reinforcing resistance.
- What they did: Enucleated hepatocyte cytoplasts bearing Au-Pt Janus nanorobots home to tumors via CXCR4 and consume lactate through gluconeogenesis, while Au-Pt boosts reactive oxygen species under acidic conditions.
- The result: In radioresistant colorectal cancer and metastatic cervical cancer models, AP/LC CXCR4 plus radiotherapy promotes immunogenic cell death, lowers myeloid and Treg populations, increases dendritic maturation and CD8+ T activation, and improves tumor control and survival.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.