Elevated mitochondrial matrix calcium induces detachment of mitochondria from lipid droplets, enhancing lipolysis in brown adipocytes.
- Open access
- 3 cites
EMBO Journal
Springer Nature · Cell & Molecular Biology · ISSN 0261-4189, 1460-2075
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- Papers this month
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Substrate-induced assembly of SecYEG-YidC facilitates membrane protein insertion without gate entry, revealing a conserved, thermodynamically driven mechanism.
- Open access
- 2 cites
Impairing autophagy in the Drosophila mushroom body triggers brain-wide presynaptic remodeling and enhances resilience, including increased sleep and lifespan.
- Open access
- 1 cites
Depleting WAPL and CTCF in mouse ESC promotes 2CLC reprogramming through chromatin organization changes, dependent on the DPPA2/DUX pathway, with a 2.5-fold increase observed.
- Open access
- 2 cites
CDK8 drives immune evasion and resistance in PDAC by remodeling the tumor microenvironment during KRAS G12D inhibition, with 50% of cases showing resistance.
- Open access
- 3 cites
Atg23 prevents inappropriate fusion of Atg9 vesicles during autophagosome formation in yeast, ensuring proper membrane delivery for autophagy.
- Open access
- 1 cites
HIR2, a plant-specific SPFH protein in Arabidopsis, regulates receptor signaling and plasma membrane organization by affecting BAK1 mobility and clustering.
- 2 cites
CSE, a calcium-binding protein, is essential for cell-cell communication and septal junction formation in multicellular cyanobacteria, linking calcium signaling to multicellularity.
AHA, a conserved archaeal ribosome-associated protein, links bacterial hibernation factors and eukaryotic energy sensors, revealing an evolutionary connection across domains.
- Open access
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AHA, a conserved archaeal ribosome-associated protein, links bacterial hibernation factors and eukaryotic energy sensors, revealing an evolutionary connection across domains.
- Open access
Hox/Meis-dependent gene regulation drives neural crest cell fate transitions in mouse cardiopharyngeal development, with significant implications for heart and valve formation.
SAGA and ATAC co-activator complexes use distinct strategies to regulate gene transcription, with implications for cancer therapy.
- Open access
Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.
- Open access
Loss of Erbin in renal tubular cells increases susceptibility to AKI by 50% and worsens renal fibrosis in mice, highlighting its protective role in kidney health.
Calreticulin mediates glycan-dependent MHC-I recycling, enabling efficient immune molecule maturation with a critical role in TAPBPR-tapasin transfer.
Target-directed microRNA degradation (TDMD) influences cell states and therapy resistance in breast cancer, with 19 key substrates identified, including miR-29b-3p and miR-33a/b-5p.
Nested TAD hierarchy creates distinct cohesion zones on replicated chromosomes, balancing sister chromatid cohesion and loop extrusion.
Presynaptic accumulation of APP-CTFβ increases synaptic activity and may drive early synaptic dysfunction in Alzheimer's disease.
Membrane-anchored perforin-2 is essential for antigen escape into the cytosol, with full-length protein mediating endocytic escape in immune cells.
Distinct tau polymorphs in Alzheimer’s, PSP, and DLB associate with unique protein networks, with 493 high-confidence interactors revealing disease-specific patterns.
- Open access
Elevated reactive oxygen species induce Paneth cell dedifferentiation and reduce antimicrobial function, impairing intestinal innate immunity during inflammation.
- Open access
Excess Met1-linked ubiquitination caused by HOIL-1 inactivation leads to solid aggregate formation and impaired autophagy in cells.
MCM10 and RECQL4 jointly activate the CMG helicase during metazoan DNA replication, with their absence causing lethal replication failure in vertebrate cells.
A novel Pseudomonas aeruginosa E3 ligase, PUL-1, was identified as a key regulator of virulence, revealing a unique mechanism of bacterial ubiquitin manipulation.
- Open access
Clustering of host N-glycans by MIC1/4/6 complex enables Toxoplasma gondii rhoptry discharge, a critical step in host cell invasion.
Mitotic slippage uniquely causes nuclear instability in whole-genome duplication, leading to highly variable nuclear deformations and altered genome organization.
- Open access
Disruption of the BRCA1 coiled-coil domain does not impair suppression of tandem duplications in mouse cells and tumor models, indicating a non-essential role in this process.
- Open access
Transient changes in H3K27me3 in C. elegans persist for multiple generations, affecting fertility and involving specific histone modifications.
- Open access
Loss of rice ZEP1 disrupts homologous recombination, causing asynapsis and chromosome fragmentation, highlighting its crucial role in meiotic genome integrity.
- Open access
Microtubule posttranslational modifications selectively regulate microtubule-associated protein interactions, supporting the tubulin code hypothesis.
Cell state transitions during tissue morphogenesis are dynamically regulated by gene expression, chromatin, and biophysical signals, enabling precise tissue formation and function.
- Open access
Terrestrialization in photosynthetic organisms is linked to significant diversification and reorganization of tRNA gene repertoires, including loss of selenocysteine tRNA and structural changes.
- Open access
FAF1 and FAF2 significantly boost p97-UFD1-NPL4 complex activity, increasing substrate unfolding efficiency by engaging key cofactors and conserved activation motifs.
- Open access
Programmable RNA editing creates tumor-specific neoepitopes, enabling immune recognition and tumor control in melanoma models with 100% editing efficiency.
Orally available Colivin traps TRPV3 in an inactive state, effectively suppressing intestinal inflammation and ulcerative colitis in mice with enhanced stability.
Ribosome-associated protein quality control (RQC) is triggered by inherent synthesis challenges of transmembrane segments in CFTR, with 20% of nascent chains arresting during translation.
Chromatin condensates, regulated by MLL4, enhance nuclear mechanosensing and prevent cGAS activation, with implications for Kabuki Syndrome.
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- Environ Res483
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- Sci Adv439
- JAMA255
- Cell Rep210
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- Nat Commun177
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- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4