Research area · week to 3 Oct 2026

Epigenetics and DNA Methylation

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Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration.
Genome Medicine · 2 Oct 2026 · Journal Article
Blood cell composition accounts for up to 53% of variation in DNA methylation age, with distinct influences on epigenetic clock measures and biological processes.
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Latest in Epigenetics and DNA Methylation

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ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis.
Cancer Research · 2 Oct 2026 · Journal Article
ALKBH5-driven epitranscriptomic changes in cancer-associated fibroblasts promote pancreatic cancer metastasis independently of primary tumor growth.
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https://jclub.com.au/a/42447266
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Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration.
Genome Medicine · 2 Oct 2026 · Journal Article
Blood cell composition accounts for up to 53% of variation in DNA methylation age, with distinct influences on epigenetic clock measures and biological processes.
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https://jclub.com.au/a/42823742
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Time matters: circadian genetics and the molecular logic of human health and disease.
Nature Reviews Genetics · 1 Oct 2026 · Review
Genetic variation and misalignment of the circadian clock significantly influence human health, disease risk, and treatment outcomes, highlighting the importance of temporal biology.
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https://jclub.com.au/a/42135507
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Written in development and lost in ageing: the grammar of cellular identity.
Nature · 1 Oct 2026 · Review
Ageing results from the progressive loss of cellular identity constraints, with 90% of age-related DNA methylation changes occurring at PRC2-bound regions in mammals.
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https://jclub.com.au/a/42816559
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KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.
EMBO Journal · 1 Oct 2026 · Journal Article
Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.
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https://jclub.com.au/a/42697963
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Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Nuclear OXCT1 reduces histone β-hydroxybutyrylation at MHC-I loci, decreasing immune gene transcription and impacting hepatocellular carcinoma response to immunotherapy.
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https://jclub.com.au/a/42204309
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An H4K20me3-CTCF switch at stable TAD boundaries enforces reversible cell state transitions
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.29.702647
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Incorporating FDR into the assessment of nanopore sequencing for the reliable detection of DNA modifications in real applications
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.19.624260
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Cis-regulation and natural selection in the evolution of human DNA methylation
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.20.700710
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A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.07.596542
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Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase.
eLife · 28 Sept 2026 · Journal Article
Cryo-EM structures reveal a bifunctional TDM enzyme with a novel channeling pathway that guides formaldehyde to a remote tetrahydrofolate site, enhancing metabolic efficiency.
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https://jclub.com.au/a/42803367
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Base modification analysis in long read sequencing data using Minimod
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.16.665072
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Average local nucleosome motion remains nearly constant during interphase in living human cells
bioRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.29.721002
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A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754493
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DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.10.15.512358
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Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754138
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A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754059
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Deaf1 regulates the coordinated repression of synaptic genes to limit synaptogenesis
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.30.621128
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Microbiota during early life windows orchestrates intestinal maturation and barrier formation in the offspring
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754204
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Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753049
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Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753842
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Sperm AluY Epimutations in Male Partners of Couples with Unexplained Recurrent Pregnancy Loss
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753615
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DOT1L shapes ncPRC1 target gene repression to maintain germinal center B-cell identity in diffuse large B-cell lymphoma.
Blood · 24 Sept 2026 · Journal Article
DOT1L regulates ncPRC1 complexes and H2AK119ub1 to sustain germinal center B cell identity in diffuse large B cell lymphoma, with 20 key gene targets identified.
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https://jclub.com.au/a/42213647
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Advancing sarcoma diagnostics with expanded DNA methylation-based classification
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.30.25330543
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ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
bioRxiv · 23 Sept 2026 · Preprint
ChromBPNet accurately predicts chromatin accessibility and regulatory variants at base resolution, outperforming larger models with a lightweight design across diverse assays and contexts.
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https://jclub.com.au/a/10.1101/2024.12.25.630221
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PANDA: Phased Analysis of DNA Amplicons for Read-Level Methylation Profiling and Heterogeneity Assessment
bioRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.01.715790
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Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma.
The American Journal of Human Genetics · 23 Sept 2026 · Expression of Concern
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https://jclub.com.au/a/42808262
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Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial cell state
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.08.30.610360
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Integrative microbiome-methylome analysis links bacterial taxa to colorectal cancer histological subtypes.
mSystems · 22 Sept 2026 · Journal Article
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https://jclub.com.au/a/42635437
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Chromatin architecture dictates epigenetic memory
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.08.717143
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