Nature Structural & Molecular Biology

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GPCR-MAPS generated over 7,500 dose-response curves for the β2 adrenergic receptor, revealing a modular activation architecture with a core network plus residues shaping quantitative parameters and bias.

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TF-MAPs maps distance-dependent, anisotropic allostery in three human disease transcription factors—HNF1A, FOXG1, and FOXP1—linking the DNA-binding interface to protein surface features.

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Mammalian SWI/SNF (BAF) ATP-dependent chromatin remodelers mobilize nucleosomes to regulate chromatin accessibility and transcriptional programs that shape cell identity and environmental responses.

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A tethered reporter screen of 730 RNA-binding proteins found 281 RBPs that significantly modulate circular RNA activity, mapping trans-acting control across circRNA metabolism stages.

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EMC’s chaperone activity is required for cotranslational assembly of heterotrimeric voltage-gated calcium channels, with loss linked to premature degradation of nascent channels.

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Cryo-EM structures reveal the TPRT initiation-state mechanism of the avian R2Tg retrotransposon, including how Cas9-guide RNA binding shapes the R2 RNA–DNA complex.

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Proximity labeling of 85 antigens on human T lymphocytes and B lymphoblasts reveals functional modules and spatial organization of the cell surface proteome, including widely dispersed versus localized antigens.

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GPCRmd-NMR integrates molecular dynamics with high-resolution NMR to enable structure-resolved analysis of 3D GPCRome dynamics across multiple GPCRs.

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Bacterial phage infection drives rapid immune activation, and structural, biochemical, and genetic studies show that conformational change, protein assembly, and spatial organization govern sensing-to-effector steps.

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A de novo Norrin-FZD4-TSPAN12-LRP5 complex structure shows two curved Norrin homodimers bridging two FZD4-TSPAN12 heterodimers, with LRP5 LA3 coordinating all interfaces.

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Phosphorylated M18BP1 activates human condensin II by inducing conformational changes that relieve autoinhibition, enabling stable DNA binding and timely mitotic DNA compaction.

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Microexons in alternative splicing account for a substantial share of localization changes, with 38% of tested isoform pairs altering protein localization in a high-content imaging screen.

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Partial agonists bound to GluA2-γ2 AMPAR complexes shift AMPAR gating by stabilizing a pre-active state, with ~17° LBD clamshell closure separating pre-active from open/desensitized states.

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Single-molecule tracing in Caenorhabditis elegans identifies three classes of megabase-scale heterochromatin domains, including condensin I-dependent sharp-boundary TAD-like domains.

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Higher-efficacy μ-opioid receptor agonists accelerate transitions of Gi G-protein AHD into an open, low-nucleotide-affinity conformation, despite the ligand acting over 70 Å away.

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The ER membrane protein complex (EMC) forms a stoichiometric supercomplex with the P5A-ATPase Spf1/ATP13A1, positioning their insertase and dislocase sites for coordinated substrate handling.

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A phosphoproteome atlas covering over 200,000 class I phosphosites across 33 human cell lines enables single-shot phosphoproteomics with 30-fold faster data processing.

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Mechanical cues in a cell’s microenvironment can produce long-term changes in cell phenotype and identity, supporting mechanical regulation of cell memory.

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HERC4 ubiquitinates S166-phosphorylated, kinase-active RIPK1 within its death domain, enabling RIPK1 oligomerization and formation of TNF-driven complex IIa and necrosome.