Epigenomics of embryogenesis in turbot.

A multiomic regulatory atlas of turbot embryogenesis maps stage-specific promoter and enhancer chromatin states, revealing strong accessibility shifts during shield-to-early segmentation.

• Why it matters: Epigenomic control of early development is well studied in model fish, but farmed fish like turbot are less characterized despite aquaculture traits depending on early embryogenesis.
• What they did: The study integrated multihistone ChIP-seq with ATAC-seq across embryonic stages and identified 14,560 active genes, with >90% differentially expressed between consecutive stages.
• The result: Chromatin accessibility reorganizes markedly during shield-to-early segmentation, transcription factor motifs track stage-specific regulatory elements, and turbot shows global transcriptomic correlation with zebrafish orthologs at matched stages.

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