Cell Research

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CD55 on tumor-encountered NK cells organizes lipid raft–LCK signaling via CD97 engagement, and restoring CD55 boosts antitumor efficacy in vivo.

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Ursodeoxycholic acid enhances cancer radioimmunotherapy in peripheral blood mononuclear cell-humanized mice by suppressing a human-biased FXR–TRIM22–STAT1 immune brake.

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Metabolic state—spanning bioenergetics, redox balance, nutrients, metal ions, inflammation-linked metabolism, and organelle function—converges across regulated cell death programs to shape susceptibility and outcomes.

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Exogenous calcitonin gene-related peptide (CGRP) more effectively reduces ischemia-reperfusion (I/R)-induced kidney injury in diabetes and older-adult mouse models with reduced renal CGRP abundance.

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Undernourished mice are more attractive to multiple mosquito vectors, linked to higher volatile aldehyde emissions from skin microbiota changes and impaired antimicrobial fatty acid secretion.

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Innate immune cytosolic sensors assemble inflammasomes and PANoptosomes to activate caspase-1 and drive lytic inflammatory cell death, linking dysregulation to diverse diseases.

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TRIM37 is required to maintain primordial germ cell identity during migration, with Trim37 deficiency causing complete PGC depletion by embryonic day 12.5.