The abstract is read at the publisher; the summary is JClub's.
Exogenous calcitonin gene-related peptide (CGRP) more effectively reduces ischemia-reperfusion (I/R)-induced kidney injury in diabetes and older-adult mouse models with reduced renal CGRP abundance.
- Why it matters: AKI and progression to CKD lack effective therapies, and the kidney’s neuroimmune circuitry—especially sensory neuron organization and function—remains unclear.
- What they did: Whole-organ tissue clearing and 3D imaging mapped nociceptive sensory fibers; TRPV1+ nociceptor ablation worsened I/R outcomes, while chemogenetic activation protected, with CGRP acting on CALCRL-RAMP1 in monocytes/macrophages via cAMP-PKA.
- The result: CGRP signaling suppresses pro-inflammatory cytokine/chemokine expression, limits myeloid infiltration and tubular injury, and in high-risk diabetic and elderly settings enables stronger I/R protection.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.