Cohesin-mediated loop extrusion reorganizes replication fork contacts to promote fork slowing and reversal during replication stress, enhancing genome stability.
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Microtubule and mitosis dynamics
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Phosphoglycerate kinase 1 (PGK1) acts as a co-adaptor with the AP2 complex, enhancing cargo recognition and promoting endocytosis independently of its enzymatic activity.
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TRI-611 is the first clinical-stage molecular glue degrader targeting ALK fusion proteins, achieving tumor regression in ALK-positive NSCLC models.
Cohesin's dual functions in genome maintenance include sister chromatid cohesion and chromatin loop extrusion, crucial for DNA repair and genome stability.
Greatwall kinase controls cytokinesis and cell cycle in AML cells via a novel pathway independent of ENSA-PP2A-B55, revealing a unique regulatory mechanism.
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Hyperphosphorylated tau disrupts microtubule envelopes and impairs lysosome transport, contributing to neurodegeneration in tauopathies like Alzheimer's disease.
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A novel ∼54-kDa protein, MSEP, encoded by the ARHGEF17-AS1 locus, is essential for mitotic spindle organization and localizes to spindle poles.
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Single-cell mapping reveals that 42% of chromosome breaks in human cells occur at common fragile sites, with 58% occurring at rare, replication-timing-dependent regions.
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Kilobase-sized indels and point mutations drive centromere evolution in Arabidopsis thaliana, with point mutations occurring nearly ten times faster than elsewhere in the genome.
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Inhibition of microhomology-mediated end joining reduces ecDNA levels and impairs cancer cell fitness by targeting TA-rich breakage sites.
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ARHGEF17-AS1 is essential for mitotic spindle integrity, regulating spindle organization through interactions with RPS3, dynein, and RNF10 during mitosis.
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Mitotic slippage uniquely causes nuclear instability in whole-genome duplication, leading to highly variable nuclear deformations and altered genome organization.
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Loss of rice ZEP1 disrupts homologous recombination, causing asynapsis and chromosome fragmentation, highlighting its crucial role in meiotic genome integrity.
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PKMYT1 inhibition induces DNA damage and cell death specifically in del(17p) multiple myeloma cells, offering a targeted therapeutic approach.
γ-tubulin associates with centromeres and influences their dynamics, with levels affecting centromere organization and response to genomic stress in human cells.
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Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, challenging previous views of it as a monomeric, nonprocessive motor.
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Cohesin-mediated loop extrusion reorganizes replication fork contacts to promote fork slowing and reversal during replication stress, enhancing genome stability.
- 1 opens in JClub
- Open access
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