PLOS Biology

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Mice trained to detect vocalizations in sound textures show better auditory-cortex encoding and detection when they can sample acoustic statistics longer, especially with higher cross-frequency correlations.

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In the kelp Laminaria pallida, asexual reproduction is linked to endoreduplication and reduced fitness, and it is retained but rarely expressed in two natural populations.

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Category learning for alien identity in a two-band auditory fMRI paradigm selectively prioritizes the identity-diagnostic frequency band, but not alien size, in expert participants.

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In wild-type Escherichia coli, between-gene differences in mutational density are not predicted by gene “importance” (protein level or essentiality) or by replication strand, with no strand-linked mutation-rate differences detected.

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The single Cryptosporidium rhoptry persists after pre-invasion discharge and acts as a conduit for multiple waves of effector secretion, enabling feeder organelle formation.

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lmx1b shows dorsal expression in paired fin mesenchyme but posterior expression in median fins, revealing a developmental asymmetry linked to appendage evolution.

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Virus-like particles enable highly efficient Cre recombination and CRISPR/Cas9 editing in porcine cells, organoids, and oocytes, especially under multiplexed delivery.

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LARM-Lmx1b dorsal determination is essential for dorsoventral patterning of zebrafish paired pectoral and pelvic fins, while being dispensable for unpaired dorsal and anal fins.

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Flow cytometry-based isolation plus ultrasensitive proteomics enables high-throughput profiling of pure Salmonella-containing phagosomes from macrophages, quantifying more proteins than prior methods at 30 min and 4 hours.

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Double knockout of sperm PLCζ1 and PLCδ4 in mice abolishes fertilization-induced Ca2+ oscillations and causes male sterility, showing both PLCs are required for egg activation.

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Alcohol consumption is linked to many cancers, but the key unresolved issue is the specific mechanisms by which ethanol promotes malignancy across the life span.

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Optogenetic manipulation of lateral hypothalamic GABAergic projections in mice shows functional segregation: LH→PVT activation is anxiogenic without changing pain, while LH→LPB activation drives contralateral pronociception without affecting affect.

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Migratory behavior is linked to higher extinction rates in ungulates, with ~80% (41 of 51) of late Quaternary extinctions involving migratory species versus 46% (95 of 207) among extant ones.

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In larval zebrafish, saccadic suppression in the optic tectum lasts over 3,000 ms and selectively boosts the salience of ecologically relevant stimuli.

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Hippocampal activity is linked to representing both unimodal and audiovisual stimuli in a PLOS Biology study, extending beyond visual-only work.

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Early-conceiving female mandrills (Mandrillus sphinx) that already have an infant show a higher probability of fetal loss than other females, in a wild mandrill study.

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Deep radiations within Zygnematophyceae were uncovered, reshaping reconstructions of algal ancestry for land plants and revealing previously under-sampled internal diversity.

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In wild mandrills, conceiving while still caring for an infant is linked to higher fetal loss probability, and infant tantrums are also associated with fetal loss.

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Multivariate fMRI shows the human hippocampus represents both auditory and visual scenes, with posterior hippocampus multisensory facilitation for congruent stimuli and anterior crossmodal decoding.

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Deep genetic structure within the Zygnematophyceae is revealed by 104 transcriptomes and 2243 loci, showing major divergence between Spirogyrales and Desmidiales and later Spirogyrales diversification.

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Mature podophage A1002 infecting carbapenem-resistant Pseudomonas aeruginosa has an elongated tail with a split nozzle and chain-like fibers, including 11 adsorption sites.

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In Pogona vitticeps, active visual sampling alternates with many-seconds ocular stillness, with saccades occurring at 3–5 Hz and state-linked pupil constriction.

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Conditional Cfl1 deletion in mouse surface ectoderm reduces spinal zippering speed by ~30% and increases spina bifida incidence by ~30%, linked to altered actin dynamics.

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CRISPR immunity in Pseudomonas aeruginosa is not universally beneficial against virulent phages, with fitness effects varying strongly and predictably across a diverse phage panel.

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Ventromedial prefrontal cortex encodes affective space with robust hexadirectional modulation, showing grid-like coordinate coding for emotion concepts across modalities during fMRI.

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HMB-PP–activated Vγ9Vδ2 human intestinal T-cells potently suppress Candida albicans growth in healthy organ cultures via an IL-22–dependent mechanism.

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Unresolved DNA bridges in Caenorhabditis elegans lem-3/ANKLE1 mutants promote stable intercellular bridges that form binucleate syncytia between touch receptor neurons and sister cells.

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A new collection reframes neurodegeneration research by placing disease within its physiological context, emphasizing the surrounding tissue microenvironment rather than only diseased neurons.

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A PLOS Biology study links developmental microbial exposure to later food avoidance via a microbiome-to-gut-to-neuron pathway, clarifying how early encounters shape adult behavior.