Rethinking neurodegeneration: Placing disease in its physiological context.

A new collection reframes neurodegeneration research by placing disease within its physiological context, emphasizing the surrounding tissue microenvironment rather than only diseased neurons.

• Why it matters: Neurodegeneration studies are often restricted to single diseases, cell types, or mechanisms, potentially missing how local tissue context shapes disease processes.
• What they did: The collection surveys approaches that look beyond diseased neurons to the surrounding tissue microenvironment to study neurodegeneration in physiological context.
• The result: This shift enables a broader view of neurodegeneration that may better capture interactions between neurons and their tissue environment.

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