Whole genome duplication through mitotic slippage causes nuclear instability.

Mitotic slippage uniquely causes nuclear instability in whole-genome duplication, leading to highly variable nuclear deformations and altered genome organization.

• Why it matters: Understanding how different routes to polyploidy affect cell stability is crucial for insights into both normal physiology and disease processes involving genome duplication.
• What they did: The study compared WGD via mitotic slippage, cytokinesis failure, and endoreplication, observing that only mitotic slippage resulted in widespread nuclear abnormalities and increased nuclear softness.
• The result: Nuclear instability from mitotic slippage was also seen in physiological polyploid cells like megakaryocytes, suggesting this pathway's unique impact on nuclear architecture and potential disease implications.