Nature Aging

AI summary · may contain errors

Aging in human natural killer (NK) cells is linked to lipid accumulation, softer cortical mechanics, disorganized immune synapses, and impaired target killing.

AI summary · may contain errors

Brain-derived mitovesicles are enriched in Alzheimer’s disease patients and 5×FAD mice, and their Ggt1 cargo drives AD-like behavioral and pathological changes in wild-type and 5×FAD mice.

AI summary · may contain errors

Age-related decline of chaperone-mediated autophagy (CMA) impairs macrophage clearance of senescent cells, increasing senescent cell persistence in mice.

AI summary · may contain errors

Age-dependent heterogeneity in activated oocyte longevity in mice shows some Act-Oos progress rapidly while others persist into late or terminal reproductive stages, supporting long-term fertility.

AI summary · may contain errors

Oral vanadyl sulfate (VS) acts as a senolytic in male mice, extending lifespan and killing senescent cells by targeting a redox-proteostasis vulnerability.

AI summary · may contain errors

Quest2Dx, a language-modeling AI for health questionnaires, screens Parkinson’s disease with AUROCs of 0.977 on PPMI Online and 0.974 on Fox Insight.

AI summary · may contain errors

A quantitative nanoparticle enrichment plus data-independent acquisition workflow enables deep proteomic profiling of 20 µl mouse serum, identifying 3,992 protein groups across ages 12–30 months.

AI summary · may contain errors

In 1,250 postmortem prefrontal cortex samples, 107 differentially methylated probes linked to Alzheimer’s disease neuropathology were found, with 38 replicated in an independent cohort (n = 139).

AI summary · may contain errors

OMC1 is required in mouse oocytes to maintain REC8-cohesin chromosome cohesion through reproductive life, suppressing age-associated chromosome segregation errors.

AI summary · may contain errors

Atorvastatin promotes bone anabolism under estrogen-deficient conditions by driving osteogenic differentiation of LEPR+ bone marrow stromal cells, including skeletal stem/progenitor cells.

AI summary · may contain errors

The Human Aging Endothelial Cell Atlas (HAECA) maps over 375,000 human endothelial cells across 12 tissues, revealing age-linked transcriptional shifts including reduced angiogenic programs in venous ECs.

AI summary · may contain errors

Cytotoxic CD4+ T cells in aged mice drive myelopoiesis and increase the neutrophil-to-lymphocyte ratio via CCL5–CCR5 signaling, with CCR5 blockade normalizing these changes.

AI summary · may contain errors

In male mice, early depletion of naive CD8+ T cells linked to accelerated antigen-agnostic “virtual memory” differentiation and thymic involution drives faster lymph node contraction and fewer local naive clones.

AI summary · may contain errors

RamanOmics identifies a conserved lipid-linked Raman signature at 1,131–1,135 cm−1 that marks p21+ senescent cells across young and old mouse lung and skin.