The abstract is read at the publisher; the summary is JClub's.
In 1,250 postmortem prefrontal cortex samples, 107 differentially methylated probes linked to Alzheimer’s disease neuropathology were found, with 38 replicated in an independent cohort (n = 139).
- Why it matters: Prior epigenome-wide studies using 450K arrays had limited CpG coverage and often tested only one neuropathological outcome, leaving gaps in how DNA methylation relates to multiple AD measures.
- What they did: The team profiled DNA methylation with the Infinium MethylationEPIC v2 array (~930,000 CpGs) and ran epigenome-wide association studies across several neuropathologic measures, including AD diagnosis, amyloid-β, and tau tangles.
- The result: DNA methylation partially mediated APOE genotype effects on AD diagnosis (proportion mediated: 8.6%, P = 2 × 10 -6 ), expanding the AD neuropathology epigenetic landscape and linking methylation to APOE-related genetic risk.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.