The abstract is read at the publisher; the summary is JClub's.
The Human Aging Endothelial Cell Atlas (HAECA) maps over 375,000 human endothelial cells across 12 tissues, revealing age-linked transcriptional shifts including reduced angiogenic programs in venous ECs.
- Why it matters: Endothelial dysfunction during aging increases cardiovascular disease risk, but a harmonized, tissue-spanning single-cell transcriptomic atlas across the adult lifespan has been missing.
- What they did: The study built HAECA, a harmonized single-cell transcriptomic compendium of 375,000+ ECs from 12 human tissues, then identified age-associated changes and a p21-linked transcriptional program using integrated analyses across in vitro and in vivo models.
- The result: Age is associated with widespread extracellular matrix and mechanotransduction signature alterations, and the p21-linked program is linked to cellular senescence, enabling a high-resolution reference for human endothelium across tissues and age.
The findingWhy it mattersWhat they didThe result
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