Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.

A roadmap calls for systems-level integration to connect microtubule molecular properties and functions with development, ageing, and disease, addressing key unexplored links.

• Why it matters: The field lacks a holistic framework bridging molecular and cellular details to broader microtubule cytoskeleton functions, including how properties change with post-translational modifications, mutations, or lattice variation.
• What they did: The authors propose integrating experimental and theoretical approaches across spatial and temporal scales, building on current microtubule research to outline future opportunities and challenges.
• The result: This integration is expected to enable new insights into essential cellular mechanisms and physiology and to clarify how microtubule dysfunction relates to a broad spectrum of human diseases.

AI summary of the abstract · may contain errors · not medical advice · read the paper.