Molecular regulators and cell interactions make the blood-brain barrier a dynamic, highly selective interface crucial for CNS health and disease.
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Nature Reviews Molecular Cell Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 1471-0072, 1471-0080
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Dynamic, reversible assembly of gene regulation complexes governs their function, with transient interactions driven by kinetic rates rather than static structures.
The outer kinetochore's KMN complex is essential for microtubule binding and mitotic checkpoint regulation, with high-precision control achieved by a few KMN units per microtubule.
Complete structural insights into the inner kinetochore and centromeric chromatin reveal critical details for chromosome segregation in eukaryotic cells.
Necroptosis involves two distinct subtypes, extrinsic and intrinsic, with over 50% of pathways triggered by membrane receptors or intracellular sensors.
DNA double-strand break repair pathway choice is governed by complex mechanisms involving chromatin modifications and key repair factors, with BRCA1-BARD1 and 53BP1 playing antagonistic roles.
Single-molecule genomics (SMG) enables detailed, genome-wide analysis of regulatory mechanisms on individual DNA molecules, revealing complex interactions and heterogeneity.
High-resolution cryo-electron microscopy reveals dynamic assembly processes in RNA polymerase II transcription initiation, with key complexes like TFIID and Mediator playing crucial roles.
High-resolution imaging reveals complex, dynamic architecture of mammalian nucleoli essential for ribosome biogenesis.
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Specialized membrane protrusions like tunnelling nanotubes and cytonemes are more prevalent and functionally diverse than previously understood, crucial for intercellular communication in tissues.
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Molecular regulators and cell interactions make the blood-brain barrier a dynamic, highly selective interface crucial for CNS health and disease.
- 5 cites
Plants activate complex molecular and cellular mechanisms, including heat shock factors and biomolecular condensates, to acclimate to heat stress, enabling survival under rising temperatures.
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