HIR2, a plant-specific SPFH protein in Arabidopsis, regulates receptor signaling and plasma membrane organization by affecting BAK1 mobility and clustering.
- 2 cites
Cellular transport and secretion
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Gp41-directed antibodies neutralize HIV-1 by allosterically stabilizing or opening Env conformations, revealing two distinct modes of neutralization with long-range effects.
- Open access
SMF-1 pilus forms antiparallel bundles that facilitate rapid biofilm initiation in Stenotrophomonas maltophilia, revealing a unique structural mechanism for bacterial colonization.
- Open access
Targeting oncomucin-driven immune suppression enhances K-ras(G12D) inhibitor effectiveness in pancreatic cancer, reducing tumor burden and immune checkpoints.
- Open access
- 1 cites
Phosphoglycerate kinase 1 (PGK1) acts as a co-adaptor with the AP2 complex, enhancing cargo recognition and promoting endocytosis independently of its enzymatic activity.
- Open access
Gβ3γ3 acts as a critical positive allosteric modulator, reorienting PLCβ3 to enhance activation and PI(4,5)P2 hydrolysis at the plasma membrane.
- Open access
Clathrin adaptors Ent5 and Sla2 drive phase separation essential for membrane trafficking, with Ent5's helix and Sla2's coiled-coil mediating condensate formation.
- Open access
MclX controls mother cell lysis in Bacillus thuringiensis by inhibiting SpoIIID, reducing cwlC expression and delaying lysis during sporulation.
- Open access
Using CD115 instead of CLEC12A improves the precision of defining human common monocyte progenitors, revealing their molecular complexity.
- Open access
LAPTM4A enhances mTORC1 signaling, promoting pathological cardiac hypertrophy in mice and humans, with deletion reducing hypertrophy and fibrosis.
Genetic variation influences in vivo protein-protein interactions in yeast, with 12,000 SNPs revealing 61 reporter PPIs and numerous piQTLs.
- Open access
- 1 cites
Unconventional protein secretion offers new design principles to enhance rapid control of extracellular protein release in mammalian cells.
- Open access
TRIM62 enhances influenza A virus entry by modulating WASH-dependent endosomal trafficking, promoting viral internalization through retromer regulation.
- Open access
NtEPF3 and NtEPFL6 peptides enhance drought tolerance in tobacco by regulating stomatal function and kinase signaling pathways.
- Open access
DcrB acts as a molecular safeguard in Escherichia coli by promoting Lpp maturation and preventing toxic inner membrane-peptidoglycan linkages, especially under stress conditions.
- Open access
Cholesterol is essential for maintaining lysosomal function during mitochondrial clearance, with significant effects observed in cellular health.
- Open access
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