Terno regulates meiotic exit and sperm differentiation in Drosophila by controlling cyclin degradation, with mutants showing extra meiotic divisions and sperm defects.
Journal of Cell Biology
Rockefeller University Press · Cell & Molecular Biology · ISSN 0021-9525, 1540-8140
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Ana1/Cep295 promotes centriole elongation in fly spermatocytes through interactions with Cep135 and microtubules, leading to overelongation.
Astrocytic cholesterol release dynamically regulates synaptic vesicle exo- and endocytosis modes, affecting presynaptic release and retrieval processes.
Lipid mediator 12-HHT activates BLT2 to promote membrane repair and prevent cell death during bacterial toxin exposure.
Mammalian kinetochores are highly elastic structures that depend on condensin for stability and proper function under spindle forces, with large-scale deformations observed during metaphase.
Myo1D directs clockwise circumferential F-actin flow, establishing cell chirality in Drosophila macrophages with a key role in organ asymmetry.
Integrins and tetraspanins facilitate CD36-actin coupling, influencing CD36 organization and signaling in vascular endothelial cells, with a significant impact on thrombospondin-1 pathways.
NLS-LARIAT enables light-controlled, reversible clustering of diverse GFP-tagged nuclear proteins in Drosophila ovary, revealing rapid, localized functions.
Extracellular mechanical signals enhance Golgi export, increasing secretory activity by up to 50% in adherent cells under mechanical stress.
Loss or dysfunction of muscle caveolae causes a range of muscle diseases, including caveolinopathies, by disrupting key cellular processes.
Malat1 long noncoding RNA is degraded during early G1 phase via a translation-dependent pathway, preventing its accumulation and influencing cancer progression.
Different β-tubulin isotypes, TBB-1 and TBB-2, uniquely contribute to acentrosomal spindle assembly and function during C. elegans oocyte meiosis, affecting bipolarity and integrity.
Esc1-mediated telomere anchoring prevents hypercluster formation in quiescent Saccharomyces cerevisiae cells, with loss of anchoring enabling clustering during metabolic shifts.
The membrane recruitment domain of BDCPs is essential for proper targeting, with mutations like L388P or E643V disrupting this process and linking to gray platelet syndrome.
Super-resolution imaging shows that CAR-T cells have altered actin structures at immune synapses, with 40% fewer actin foci and persistent microvilli-like protrusions.
Physiological activation of the unfolded protein response (UPR) during meiosis in budding yeast reveals an ancient adaptive role, with 100% of cells showing ER reorganization.
Loss of dcert in Drosophila impairs G-protein-coupled PLC signaling by disrupting membrane contact site function, reducing photoreceptor response by 50%.
Endogenous UPR is essential for gametogenesis in budding yeast, supporting ER integrity and meiosis with only mild target induction.
Three-dimensional imaging uncovers novel structural features and variability in desmosomes across epithelial and tissue models, including gaps within the outer dense plaque.
Precise spatial patterning of zygotic genome activation is essential for normal embryo development, with inverted patterns causing apoptosis in vertebrate embryos.
Mechanical signals from cell spreading directly influence Golgi function, modulating its secretory output in a feedback loop that supports cell spreading.
Chromosomes in mitosis absorb spindle forces through stiff linkages and flexible centromeres, maintaining grip under substantial microtubule tension.
A conserved dimeric coiled-coil hairpin structure mediates autoinhibition of the CM1 domain, preventing γ-TuRC binding in humans and flies.
Alx1 and Vid27 define a novel Cmp7- and ESCRT-independent pathway for nuclear envelope assembly in fission yeast, crucial for nuclear integrity.
Golgiphagy varies significantly across cell types and tissues, with up to 2.5-fold higher activity in renal proximal tubules and cerebellar neurons in vivo.
Loss of rhomboid protease Rhbdl2 in zebrafish enhances wound repair by increasing macrophage recruitment and cell proliferation, with a 2-fold rise in macrophage migration speed.
Avl9, a DENN domain protein, acts as a GTPase-activating protein for Arf1, with conserved activity in humans and a role in cell migration.
Ribosomal precursor assembly states dictate nucleolar material properties by modulating NPM1 dynamics, with early intermediates slowing and abortive precursors speeding up the process.
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