Visualizing the Golgi apparatus and Golgiphagy in vivo.

Golgiphagy varies significantly across cell types and tissues, with up to 2.5-fold higher activity in renal proximal tubules and cerebellar neurons in vivo.

• Why it matters: Understanding Golgi organization and turnover is crucial for insights into cellular homeostasis and disease, yet its regulation in living tissues remains largely unknown.
• What they did: Researchers developed two reporter mouse lines for visualizing Golgi structure and Golgiphagy, enabling detailed single-cell analysis across multiple tissues under different conditions.
• The result: The models revealed that Golgiphagy is spatially heterogeneous and increases in response to stressors like starvation and inflammation, providing new tools to study Golgi dynamics in vivo.