Are plant annexins new components of protein complexes at membrane contact sites?

AlphaFold-Multimer modeling and confocal microscopy support that Arabidopsis annexins may participate in membrane contact site (MCS) protein complexes, with all eight predicted to carry FFAT motifs.

• Why it matters: Animal annexins AnxA6 and AnxA1 are linked to protein complexes that help form MCSs, but whether plant annexins join similar complexes is unknown.
• What they did: The study combined bioinformatic motif prediction (FFAT), AlphaFold-Multimer structural modeling, and fluorescence confocal microscopy to assess Arabidopsis annexin localization and potential partners.
• The result: It proposes Arabidopsis annexins as new putative MCS players, suggesting possible complexes with plant dynamin, Rab GTPase, TBC1D15, FIS1, and VAMP homologs at ER–organelle contacts.

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