Self-organizing human dual neural organoids (hPCOs) reveal Wnt signaling's bidirectional role in central and peripheral nervous system development, modeling key disease defects.
Developmental Cell
Elsevier BV · Cell & Molecular Biology · ISSN 1534-5807, 1878-1551
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Nodal/Smad2 signaling maintains embryonic diapause in mice by repressing lipid storage pathways in blastocysts.
Protein turnover rate determines species-specific developmental timing by regulating embryonic progression.
Pax7 is expressed in multiple skeletal muscle cell types, not exclusively in muscle stem cells, challenging its role as a definitive marker.
VHL-HIF signaling axis with HIF1α and HIF2α directs iNKT cell survival and differentiation during thymic development.
Senescent cells shed large cytoplasmic fragments that enhance their survival and may facilitate communication with neighboring cells.
Synergid cells in flowering plants are essential for guiding pollen tubes and ensuring successful fertilization, with their functions vital for plant fertility.
Malignant tumor clones hijack interclonal Hedgehog-Wnt signaling to convert cell competition into a driver of tumor growth, as shown in Drosophila and human pancreatic cancer.
VHL-HIF signaling axis is essential for iNKT cell development, with VHL deletion impairing maturation and subset differentiation, affecting immune responses and tumor surveillance.
Proteasome activity differences between mouse and human neural progenitors regulate developmental timing, with faster proteasome function in mice accelerating neural differentiation.
Confined melanoma cells polarize migration by restricting EGFR mobility at the bleb rear, driven by CD44 and ERM proteins, independent of directional cues.
Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages, including fibro-adipogenic progenitors, that persist into adulthood, with significant implications for muscle regeneration.
Protein stability differences across species underlie the slower developmental tempo in humans compared to mice, with human proteins degrading more slowly.
The ARLA1A-NAC089 module regulates ER phagy and UPR to sustain cellular balance in plants, with ARLA1A inhibiting ER phagy via NAC089 during stress.
Nodal/Smad2 signaling is essential for maintaining embryonic diapause by repressing Pparg-mediated lipid metabolism, preventing lipid accumulation during dormancy.
Elongating human heart organoids (EHOs) mimic early cardiac morphogenesis, including elongation, looping, and axial organization, with a 50% reduction in length upon TBX5 deletion.
ER-localized transcription factor NAC089 functions as a molecular switch controlling plant cell fate between adaptation and death under stress.
Senescent cells survive by forming adhesion-dependent fragments called SCAFs that contain damaged organelles and rupture to release pro-inflammatory proteins.
PRR9 protein condensation modulates plant circadian clock speed in response to high temperatures, ensuring temperature compensation.
PRR9 acts as a key thermoregulatory hub in Arabidopsis, enabling temperature adaptation by promoting liquid-liquid phase separation and modulating circadian gene expression at high temperatures.
Depleting SPT5 in Drosophila embryos causes stage-specific shifts in RNA polymerase II positioning, disrupting gene regulation during development.
Natural variation in TOLS1 influences rice salt tolerance by modulating OsRacB-Ca(2+) signaling, with the TOLS1 A allele reducing tolerance more than G.
Reactive oxygen species, especially hydrogen peroxide, regulate key developmental processes by modulating signaling pathways through reversible cysteine oxidation.
Prolonged cold exposure boosts Arabidopsis regeneration by 50% through epigenetic activation of key developmental genes.
Tissue tension enables β-catenin phosphorylation to promote mesoderm formation in human embryonic stem cells, with 50% reduction in Brachyury (T) expression when disrupted.
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Pulmonary cold sensing via Club cells activates adipose thermogenesis, with KCNK2 channels mediating cold detection in the lungs of mice.
Plant-derived phytocytokines trigger stronger immune responses than microbial patterns across Arabidopsis root cell types and zones, with response strength linked to pathogen invasion sites.
High-resolution live imaging reveals two distinct phases of sperm remodeling and movement during mammalian fertilization, including in human oocytes.
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